Herpes zoster
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Herpes zoster blieren op 'e nekke en skouder
References
Shingles, feroarsake troch de reaktivearring fan it varicella zoster-firus ferantwurdlik foar wetterpokken, treft jierliks sawat 1 miljoen minsken yn 'e Feriene Steaten, mei in libbensrisiko fan 30%. Dy mei ferswakke ymmúnsysteem binne signifikant mear gefoelich foar it ûntwikkeljen fan gordelroos, mei symptomen dy't typysk begjinne mei malaise, hoofdpijn, en in mylde koarts, folge troch ûngewoane hûdsensaasjes in pear dagen foar it ferskinen fan in útslach. Dizze útslach, dy't meastentiids yn in spesifyk gebiet fan it lichem ferskynt, giet oer in wike oant tsien dagen troch fan dúdlike blieren nei krustige wûnen. Snelle behanneling mei antivirale medisinen (acyclovir, valacyclovir, or famciclovir) binnen 72 oeren nei útslach is krúsjaal. Postherpetyske neuralgie, in mienskiplike komplikaasje karakterisearre troch langere pine yn it troffen gebiet, beynfloedet sawat ien op fiif pasjinten en fereasket trochgeande behear mei medisinen lykas gabapentin, pregabalin, of bepaalde antidepresinten, tegearre mei topike aginten lykas lidocaine of capsaicin. Faksinaasje tsjin it varicella zoster-firus wurdt oanrikkemandearre foar folwoeksenen fan 50 jier en âlder om it risiko op gordelroos te ferminderjen.
Shingles, caused by the reactivation of the varicella zoster virus responsible for chickenpox, affects around 1 million people annually in the United States, with a lifetime risk of 30%. Those with weakened immune systems are significantly more prone to developing shingles, with symptoms typically starting with malaise, headache, and a mild fever, followed by unusual skin sensations a few days before the appearance of a rash. This rash, usually appearing in a specific area of the body, progresses from clear blisters to crusted sores over a week to ten days. Prompt treatment with antiviral medications (acyclovir, valacyclovir, or famciclovir) within 72 hours of rash onset is crucial. Postherpetic neuralgia, a common complication characterized by prolonged pain in the affected area, affects about one in five patients and requires ongoing management with medications such as gabapentin, pregabalin, or certain antidepressants, along with topical agents like lidocaine or capsaicin. Vaccination against the varicella zoster virus is recommended for adults aged 50 and above to reduce the risk of shingles.
Shingles, caused by the reactivation of the varicella zoster virus responsible for chickenpox, affects around 1 million people annually in the United States, with a lifetime risk of 30%. Those with weakened immune systems are significantly more prone to developing shingles, with symptoms typically starting with malaise, headache, and a mild fever, followed by unusual skin sensations a few days before the appearance of a rash. This rash, usually appearing in a specific area of the body, progresses from clear blisters to crusted sores over a week to ten days. Prompt treatment with antiviral medications (acyclovir, valacyclovir, or famciclovir) within 72 hours of rash onset is crucial. Postherpetic neuralgia, a common complication characterized by prolonged pain in the affected area, affects about one in five patients and requires ongoing management with medications such as gabapentin, pregabalin, or certain antidepressants, along with topical agents like lidocaine or capsaicin. Vaccination against the varicella zoster virus is recommended for adults aged 50 and above to reduce the risk of shingles.
Herpes zoster hat de neiging faker foar te kommen by minsken fan 50 jier en âlder, dyjingen mei ferswakke ymmúnsysteem, en dyjingen dy't immunosuppressive medisinen nimme. It wurdt trigger troch de reaktivearring fan it varicella-zoster-firus, itselde firus dat wetterpokken feroarsaket. Symptomen lykas koarts, pine en jeuk geane gewoanlik foar it ferskinen fan 'e karakteristike útslach. De meast foarkommende komplikaasje is post-herpetyske neuralgie, dat is oanhâldende nerve-pine nei't de útslach ferdwynt. De risikofaktoaren en komplikaasjes dy't ferbûn binne mei herpes zoster fariearje ôfhinklik fan leeftyd, ymmúnsûnens, en timing fan inisjatyf fan behanneling. Faksinaasje foar yndividuen fan 60 jier en boppe is oantoand om it foarkommen fan herpes zoster en post-herpetyske neuralgie signifikant te ferminderjen. Begjin fan antivirale medisinen en pine-relievers binnen 72 oeren nei it begjin fan útslach kin de earnst en komplikaasjes fan herpes zoster en post-herpetyske neuralgie ferminderje.
Herpes zoster tends to occur more frequently in people aged 50 and older, those with weakened immune systems, and those taking immunosuppressant medications. It's triggered by the reactivation of the varicella-zoster virus, the same virus that causes chickenpox. Symptoms like fever, pain, and itching commonly precede the appearance of the characteristic rash. The most common complication is post-herpetic neuralgia, which is persistent nerve pain after the rash clears up. The risk factors and complications associated with herpes zoster vary depending on age, immune health, and timing of treatment initiation. Vaccination for individuals aged 60 and above has been shown to significantly reduce the occurrence of herpes zoster and post-herpetic neuralgia. Starting antiviral medications and pain relievers within 72 hours of rash onset can lessen the severity and complications of herpes zoster and post-herpetic neuralgia.
Herpes zoster tends to occur more frequently in people aged 50 and older, those with weakened immune systems, and those taking immunosuppressant medications. It's triggered by the reactivation of the varicella-zoster virus, the same virus that causes chickenpox. Symptoms like fever, pain, and itching commonly precede the appearance of the characteristic rash. The most common complication is post-herpetic neuralgia, which is persistent nerve pain after the rash clears up. The risk factors and complications associated with herpes zoster vary depending on age, immune health, and timing of treatment initiation. Vaccination for individuals aged 60 and above has been shown to significantly reduce the occurrence of herpes zoster and post-herpetic neuralgia. Starting antiviral medications and pain relievers within 72 hours of rash onset can lessen the severity and complications of herpes zoster and post-herpetic neuralgia.
De klinyske proeven foar goedkarring jouwe oan dat it live zoster-faksin sawat 50 oant 70% wurket, wylst it rekombinante faksin better prestearret, fariearjend fan 90 oant 97%. Yn echte wrâldstúdzjes stypje se de befinings fan 'e proeven, en litte sjen dat it live faksin sawat 46% effektyf is, wylst de rekombinante sawat 85% is.
The pre-licensure clinical trials show the efficacy of the live zoster vaccine to be between 50 and 70% and for the recombinant vaccine to be higher at 90 to 97%. Real-world effectiveness studies, with a follow-up of approximately 10 years, were reviewed in this article. These data corroborated the efficacy studies, with vaccine effectiveness being 46% and 85% for the live and recombinant vaccines, respectively.
The pre-licensure clinical trials show the efficacy of the live zoster vaccine to be between 50 and 70% and for the recombinant vaccine to be higher at 90 to 97%. Real-world effectiveness studies, with a follow-up of approximately 10 years, were reviewed in this article. These data corroborated the efficacy studies, with vaccine effectiveness being 46% and 85% for the live and recombinant vaccines, respectively.
Waterpokken, ek wol varicella neamd, ûntstiet út 'e earste ynfeksje mei it firus, typysk foarkomt yn' e jeugd of adolesinsje. As de wetterpokken ienris genêzen is, kin it firus jierren of desennia ynaktyf (sliepend) bliuwe yn minsklike senuwsellen, wêrnei't it opnij aktivearje kin. Herpes zoster resultaten as it sliepende varicella firus wurdt reaktivearre. Dan reizget it firus lâns nerve-lichems nei nerve-einen yn 'e hûd, en produsearret blieren. Tidens in útbraak fan herpes zoster kin bleatstelling oan it varicellafirus fûn yn herpes zoster blieren wetterpokken feroarsaakje by ien dy't noch gjin wetterpokken hân hat.
Risikofaktoaren foar reaktivaasje fan it sliepende firus omfetsje âlderdom, minne ymmúnfunksje, en it hawwen fan wetterpokken foar 18 moannen âld. Varicella zoster firus is net itselde as herpes simplex firus, hoewol beide hearre ta deselde famylje fan herpesviruses.
Herpes zoster faksinen ferminderje it risiko fan herpes zoster mei 50% oant 90%. It fermindert ek tariven fan postherpetyske neuralgie, en, as herpes zoster optreedt, de earnst dêrfan. As herpes zoster ûntwikkelet, kinne antivirale medisinen lykas aciclovir de earnst en doer fan 'e sykte ferminderje as binnen 72 oeren nei it ferskinen fan' e útslach begon.
○ Behanneling
As de lesions rap ferspriede, sjoch jo dokter sa gau mooglik foar antivirale behanneling.
Sawol antivirale medisinen as neuralgie-medikaasjes binne ferplicht. Jo moatte rêste en stopje mei it drinken fan alkohol.
#Acyclovir
#Fancyclovir
#Valacyclovir
#Gabapentin
#Pregabalin